RTE 1 / 12 The Irish will take on hosts Scotland in front of a packed stadium at Twickenham on Saturday.
The Guinness PRO14 side have already secured a home World Cup qualification fixture with hosts Wales in 2019, and are hoping to make their home debut in the competition next season.
A date has yet to be confirmed but it is expected to be a short away trip to Dublin.
The Irish are already unbeaten in their last seven matches at home, with all three victories coming by five points or less.
The fixture will be a big test for both sides, with the gap between them at the top of the PRO14 table at this stage closing.
The PRO14 competition has been one of the most competitive leagues in the world, with each side competing in their home country and all of the top six sides having played in the last four.
The competition has seen a number of European clubs come through with successful European campaigns, including the likes of FC Krasnodar in Russia, FC Ingolstadt in Germany and FC Paderborn in Austria.